Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice.

ABSTRACT:

Background

Exercise is an effective intervention for obesity and type 2 diabetes, with significant physiological benefits over pharmacological interventions. However, there is limited preclinical data available comparing endurance and resistance exercise for the impacts on obesogenic pathology and glycemic control.

Methods

Male mice were subjected to 8 weeks of diet-induced obesity (DIO) by high-fat diet (HFD) feeding concurrent with voluntary wheel running (endurance exercise (E_EX)) or weightlifting (resistance exercise (R_EX)). Sedentary (SED) mice fed on normal chow (NC) or HFD were used as controls.

Results

E_EX and R_EX interventions significantly attenuated weight gain vs. HFD-SED due to reduction of fat mass, not changes

SUBMITTER: Shute RJ 

PROVIDER: S-EPMC12816905 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature