Contribution of local amyloid-β and tau burden to hypometabolism in autosomal-dominant Alzheimer's disease.

ABSTRACT: Glucose hypometabolism is observed in early Alzheimer's disease. However, there are regional discrepancies in hypometabolism and Alzheimer's pathological markers. We examined the local and global contributions of amyloid-β and tau pathology to glucose metabolism and their interplay in memory decline in Presenilin-1 E280A mutation carriers and non-carriers from the largest autosomal-dominant Alzheimer's disease kindred. This cross-sectional study included 43 mutation carriers (6 cognitively impaired) and 39 non-carriers from the Colombia-Boston Biomarker Study. Glucose metabolism was assessed with [18F]fluorodeoxyglucose PET, and memory performance with the Consortium to Establish a Registry for Alzheimer's Disease word list learning. A subgroup of 22 carriers and 26 non-carriers additional

SUBMITTER: Tristao-Pereira C 

PROVIDER: S-EPMC12816921 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature