Ketamine treatment alleviates suicide ideation in high-risk populations: a systematic review and meta-analysis.

ABSTRACT:

Aims

To synthesize the available experimental study evidence to estimate the effects of ketamine on suicide ideation (SI) in high-risk individuals.

Methods

We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Double-blind randomized controlled trials and open-label studies investigating the safety and effectiveness of ketamine on SI published up to October 2025 were identified. Data were pooled using random-effects meta-analysis. The main outcome was standardized mean difference on SI in high-risk individuals. Secondary outcomes were the percentage of adverse events and the moderator effects.

Results

We identified 21 studies with a total of 927 participants meeting our

SUBMITTER: Tang W 

PROVIDER: S-EPMC12816934 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature