GDF-15 Levels in Cirrhosis Are Linked to Hepatic Fibrogenesis, Bacterial Translocation, and Worse Clinical Outcomes.

ABSTRACT:

Background &aims

Growth differentiation factor-15 (GDF-15), a cell stress-induced cytokine, is implicated in liver disease pathophysiology. We investigated GDF-15 in cirrhosis, focusing on its association with disease-driving pathomechanisms, platelet function, hepatic decompensation, and mortality.

Methods

We included patients with cirrhosis undergoing hepatic venous pressure gradient (HVPG) measurement at the Vienna General Hospital. Platelet surface P-selectin and glycoprotein IIb/IIIa (GPIIb/IIIa) expression after agonist stimulation were assessed by flow cytometry as platelet activation markers. GDF-15 serum levels were quantified by electrochemiluminescence immunoassay.

Results

Among 106 patients (median age 55.1 years; 70.8% male), median GDF-15 was 2880 (1850-

SUBMITTER: Hofer BS 

PROVIDER: S-EPMC12816942 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature