IGF2 supports glioblastoma growth and immune evasion through a combination of tumor cell-intrinsic and -extrinsic mechanisms.

ABSTRACT:

Abstract

BackgroundGIntratumoral and intertumoral heterogeneity combined with immunosuppressive tumor microenvironments (TME) contribute to the poor outcomes associated with glioblastoma (GBM). Well-characterized immunocompetent models that recapitulate human GBM features are urgently needed to identify targets in the TME and develop novel therapeutics. Here, we used multiomic approaches to characterize syngeneic mouse brain tumor stem cell lines in vitro and in orthotopically engrafted tumors.

Methods

Whole-genome sequencing, transcriptomics, ATAC-sequencing, and imaging mass cytometry were used to characterize syngeneic brain tumor stem cell lines derived from Trp53^+/-/Nf1^+/- C57Bl6 mice. Mouse and human bulk, single-cell, and spatial se

SUBMITTER: Heemskerk KM 

PROVIDER: S-EPMC12817070 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature