ROS-Triggered Microgels for Programmable Drug Release in Volumetric Muscle Loss Repair.

ABSTRACT: Volumetric muscle loss (VML), frequently resulting from traumatic or surgical damage, causes significant muscle mass depletion and fibrosis, and presents major challenges to effective regeneration. In this study, reduced graphene-containing hyaluronic acid microgels (rGHMs) are developed as a multifunctional platform for reactive oxygen species (ROS)-scavenging and ROS-responsive drug delivery to treat VML. The rGHMs are synthesized via a water-in-oil emulsion and subsequent chemical reduction. rGHMs demonstrate superior antioxidative capability, curcumin loading efficiency, and ROS-mediated drug release properties compared to HA microgels (HMs) and unreduced graphene-oxide containing HA microgels (GHMs). In particular, curcumin-loaded rGHMs (Cur/rGHMs) significantly facilitate curcumin re

SUBMITTER: Lee S 

PROVIDER: S-EPMC12817110 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature