Metabolome Atlas of Brain Reveals Regional Shared and Unique Metabolic Drifts in Response to Type 2 Diabetes in Male Mice.

ABSTRACT: Type 2 diabetes (T2D), with continuously increasing incidence worldwide, impairs not only peripheral organs but also the central nervous system. However, the brain-region-specific metabolic signature of T2D remains unknown, which is crucial for understanding T2D neurological complications' mechanism and developing intervention. In this study, we constructed a metabolome atlas of T2D and control brain in male mice from 7 anatomical regions using liquid chromatography-mass spectrometry-based metabolomic and lipidomic techniques. In total, 673 metabolites were identified, including energy substrates, amino acids, neurotransmitters, phospholipids, and signaling lipids. We found that the mouse brain displayed region-specific metabolic architecture; however, functionally connected regions (cereb

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12817114 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature