Visible Light Induced DLP-Printed Oxygen-Releasing TPMS Scaffolds Mitigate Early Hypoxia in Bone Defects.

ABSTRACT: Oxygen deprivation within large or poorly vascularized bone defects remains a key barrier to successful regeneration, especially during the early postimplantation period before vascular ingrowth. Here, the development of COSnPPOD (CaO₂-Silica NP Platform for Osteogenic Development) is reported, a visible light digital light processing-printed hydrogel scaffold that integrates oxygen-releasing nanoparticles (NPs) within a Primitive-type triply periodic minimal surface architecture. The scaffold combines a gelatin methacrylate-poly(ethylene glycol) diacrylate matrix with calcium peroxide (CaO₂)-loaded hollow silica NPs, enabling localized, short-term oxygen release while preserving structural fidelity. COSnPPOD scaffolds demonstrate favorable degradation kinetics, tunab

SUBMITTER: Timoshenko AB 

PROVIDER: S-EPMC12817115 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature