Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.

ABSTRACT: Puberty is a critical developmental process that is associated with changes in pubertal (or steroid) hormone levels, which are believed to influence adolescent behaviour via their effects on the developing brain. So far, there are limited and inconsistent findings regarding the relationship between steroid hormones and brain structure and function in adolescent females, with many existing studies employing small sample sizes. Thus, in this study, we explored the association between oestradiol (E2), testosterone (Tes), and dehydroepiandrosterone (DHEA) and brain structure (gray matter volume, sulcal depth, cortical thickness, and white matter microstructure) and function (resting-state connectivity, emotional n-back task-related function) in 3024 adolescent females (age 8.92-13.33 years, me

SUBMITTER: Khetan M 

PROVIDER: S-EPMC12817136 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature