Differences and Compatibility between Human and Porcine Fibrinolytic Components toward Plasmin Generation and Fibrin Degradation.

ABSTRACT:

Abstract

Background

Fibrinolysis is the process of blood clot breakdown by the enzyme plasmin. Despite increased usage of large animals such as pigs to study fibrinolysis in human disease models, a comprehensive study comparing the human and porcine fibrinolytic factors has not been reported.

Objective

To directly compare and characterize structural and functional differences between human and porcine fibrinolytic factors.

Methods

Using human or porcine source of plasminogen, tissue-type plasminogen activator (tPA), and fibrinogen, we investigated how various permutations of the three fibrinolytic factors affect overall plasmin generation. Human or porcine plasmin breakdown of fibrin generated from human or porcine fibrinogen was also investigated using turbid

SUBMITTER: Kim PY 

PROVIDER: S-EPMC12817190 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature