Alkene Borylation-Hydrogenation Enables Highly Active, Site-Selective Cobalt-Catalyzed Borylation.

ABSTRACT: A method for promoting highly active and site-selective cobalt-catalyzed C(sp²)-H arene borylation is described. Addition of tert-butyl ethylene (TBE) increased the activity of the cobalt-catalyzed borylation of electron-rich arenes. With monosubstituted anisoles and anilines, synthetically useful site-selectivities favoring the meta-position of the ring were observed. Monitoring the catalytic reaction in situ by ¹H NMR spectroscopy established a borylation-hydrogenation sequence of tert-butyl ethylene as being responsible for the increased catalytic activity where borylation of the alkene preceded functionalization of the arene. Added or in situ generated trans-^tBuCH═CHBPin served as the active H₂ accept

SUBMITTER: Shimozono AM 

PROVIDER: S-EPMC12817211 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature