Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries.

ABSTRACT: To effectively reduce vision loss due to age-related macular generation (AMD) on a global scale, knowledge of its genetic architecture in diverse populations is necessary. A critical element, AMD risk profiles in African and Hispanic/Latino ancestries, remains largely unknown. We combined data in the Million Veteran Program with five other cohorts to conduct the first multi-ancestry genome-wide association study of AMD and discovered 63 loci (30 novel). We observe marked cross-ancestry heterogeneity at major risk loci, especially in African-ancestry populations which demonstrate a primary signal in a major histocompatibility complex class II haplotype and reduced risk at the established CFH and ARMS2/HTRA1 loci. Dissecting local ancestry in admixed individuals, we find significantly smalle

SUBMITTER: Gorman BR 

PROVIDER: S-EPMC12817227 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature