Clustered cardiometabolic risk in pregnancy and dysmenorrhea in offspring: Results from a prospective birth cohort study.

ABSTRACT:

Background

Dysmenorrhea, a common gynaecological complaint, is often underdiagnosed, particularly in adolescents. The Developmental Origins of Health and Disease hypothesis suggests that maternal cardiometabolic conditions during pregnancy may influence offspring reproductive health. We investigated whether cardiometabolic risk (CCMR) is associated with dysmenorrhea risk in offspring and whether early-puberty BMI and menarcheal age mediate these associations.

Methods

Data was from the Amsterdam Born Children and their Development cohort. A total of 982 mother-daughter pairs were included. Maternal CCMR included pre-pregnancy body mass index (BMI), blood pressure, glucose, triglycerides and Apolipoprotein A1. Dysmenorrhea was defined as menstrual abdominal/back pain requiring

SUBMITTER: Zhou S 

PROVIDER: S-EPMC12817236 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature