Target trial emulation of statin discontinuation in multimorbid older adults with polypharmacy.

ABSTRACT:

Background

The benefit of statins in multimorbid older adults is controversial. Prior observational studies evaluating statin discontinuation in older adults were retrospective cohorts, did not focus on multimorbidity, or lacked adjustment for geriatric syndromes. We aimed to assess the effect of statin discontinuation on cardiovascular and mortality outcomes using the target trial emulation framework.

Methods

We conducted a prospective cohort study using data from the OPERAM trial in adults aged ≥70 years with ≥3 chronic conditions and ≥5 chronic drugs, comparing statin discontinuation to continuation. The primary composite outcome was cardiovascular events or all-cause mortality at 12 months. We calculated adjusted hazard ratios (HR) using weighted pooled logistic regressi

SUBMITTER: Aponte Ribero V 

PROVIDER: S-EPMC12817241 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature