Disodium Cromoglycate Attenuates the Depressive-Like Behaviors in Mice by Inhibiting Neuroinflammation.

ABSTRACT:

Aims

Emerging evidence indicates that mast cells (MCs) may play a crucial role in the pathogenesis of major depression disorder (MDD). This study aimed to investigate whether the mast cell membrane stabilizer Disodium cromoglycate (DSCG) could ameliorate depressive-like behaviors by attenuating mast cell-mediated neuroinflammation.

Methods

Lipopolysaccharide (LPS)-induced and chronic restraint stress (CRS)-induced mouse models were induced in C57BL/6 mice to evaluate the therapeutic effect of the DSCG. Depressive-like behaviors were assessed using the sucrose preference test (SPT), tail suspension test (TST), and forced swimming test (FST). Histopathological and molecular changes were examined through immunofluorescence, western blot, RT-qPCR, and ELISA.

Results

First

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC12817297 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature