Prospective molecular classification of endometrial carcinomas: institutional implementation, practice, and clinical experience.

ABSTRACT: The comprehensive genomic analysis of endometrial carcinoma (EC) by The Cancer Genome Atlas (TCGA) led to the discovery of four distinct and prognostically significant molecular subgroups. Molecular classification has the potential to improve risk-stratification when integrated with clinicopathologic features and has recently been included in national and international patient management EC guidelines. Thus, the adoption of molecular classification into routine pathologic and clinical practice is likely to grow significantly in the upcoming years. Establishing an efficient and standardized workflow for performing molecular classification on ECs, and reporting both the molecular and histologic findings in an integrative manner, is imperative. Here we describe our effort to implement rapid a

SUBMITTER: Devereaux KA 

PROVIDER: S-EPMC12817303 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature