Uterine artery transcriptomic signatures of e-cigarette aerosol exposure in pregnancy.

ABSTRACT: Electronic cigarette (e-cig) use among U.S. adults has shifted notably, with increased adoption among younger adults and middle-aged individuals transitioning from traditional cigarettes. We herein investigated the impact of gestational e-cig aerosol exposure on uterine artery (UA) transcriptome. Timed-pregnant Sprague-Dawley rats were randomly assigned to either the pair-fed Control or the E-cig group before initiation of vaping (4 s e-cig vapor every 2 min, two episodes of 1.5 h each; gestational day (GD) 5 until GD 20). Maternal weight and placental efficiency were not altered, whereas there was a significant deficit in fetal body weight and crown-rump length in the E-cig group on GD 21. Twenty three genes were significantly upregulated, while 40 genes were downregulated in the uterine

SUBMITTER: Carabulea AL 

PROVIDER: S-EPMC12817338 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature