Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans.

ABSTRACT:

Context

Previous animal studies show association between osteocalcin (OC) and type 2 diabetes-related quantitative traits (QTs), with some suggesting these effects being mediated by adipokines. Replication in humans has been inconsistent.

Objective

We aimed to assess the association between osteocalcin and type 2 diabetes-related QTs and the roles of adipokines on the association between OC and glucose metabolism.

Methods

We used data from the BetaGene study, which is a cross-sectional family-based study of Mexican Americans from Los Angeles County. We tested the association between type 2 diabetes-related QTs and OC, including inactive (OC-inactive) and active (OC-active) forms, in 867 Mexican Americans without type 2 diabetes from 342 families. We also assessed the

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12817364 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature