Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs.

ABSTRACT: Multiple sclerosis is a neurological autoimmune disease with sex-imbalanced incidence; in the USA, the disease is more likely to affect females at a ratio of 3:1. In addition, males are more likely to have a more severe disease course at time of diagnosis. Questions about both causes and downstream effects of this disparity remain. We aim to investigate gene expression differences at a cellular level while considering sex to discover fine-scale sex disparities. These investigations could provide new avenues for treatment targeting, or treatment planning based on sex.Public single-nuclei RNA-sequencing data from three publications of progressive MS including control brains were analysed using the Seurat R package. Differential gene and pathway expression was looked at both within a specific

SUBMITTER: LaBarre BA 

PROVIDER: S-EPMC12817420 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature