D-limonene inhibits the growth of Fusarium proliferatum by decreasing H3K9ac and H3K27ac modifications.

ABSTRACT:

Background

Fusarium proliferatum, a major pathogen causing root rot in Panax notoginseng, severely threatens sustainable cultivation. While chemical pesticides face resistance and environmental risks, plant-derived alternatives are urgently needed. D-limonene, a natural monoterpene with broad antimicrobial activity, remains unexplored against F. proliferatum.

Results

D-limonene strongly inhibited F. proliferatum growth: 200 mM suppressed hyphal growth by 73.89%, reduced sporulation by 73.6%, and impaired conidia germination. It disrupted membrane integrity, increasing extracellular conductivity by 64.3% within 4 h. Transcriptomics revealed 1,134 upregulated and 1,240 downregulated genes, with downregulated genes enriched in ribosomal translation and endoplasmic reticulum pro

SUBMITTER: Zhou SW 

PROVIDER: S-EPMC12817427 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature