MYBL2 regulates the expression of CENPF in lung adenocarcinoma and promotes tumor development and metastasis through AKT pathway activation.

ABSTRACT:

Objectives

Lung adenocarcinoma (LUAD) is a major global health burden with high mortality. Elevated expression of MYBL2 and CENPF is correlated with unfavorable clinical outcomes in LUAD. However, the relationship between MYBL2 and CENPF and the downstream signaling pathways of MYBL2 and CENPF in LUAD remains elusive.

Methods

We investigated MYBL2 and CENPF expression in TCGA data and clinical LUAD samples, identifying a significant correlation. Functional studies in A549 cells demonstrated that MYBL2 acts upstream of CENPF, promoting tumor proliferation and migration. This oncogenic effect was mediated through AKT signaling, as AKT inhibition phenocopied the suppressive effects of CENPF knockdown.

Results

Analysis of TCGA data and clinical specimens confirmed signifi

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12817451 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature