Unraveling the potential mechanisms of Xiaochaihu decoction alleviates metabolic associated fatty liver disease (MAFLD) by integrated transcriptomics, metabolomics, and network pharmacology.

ABSTRACT:

Background

Metabolic associated fatty liver disease (MAFLD) has currently emerged as the predominant form of chronic liver diseases nowadays, with a high morbidity. Nevertheless, the general remission rate of current treatments for MAFLD remains unsatisfactory. The traditional Chinese medicine formulation Xiaochaihu decoction (XCHD) alleviates triglyceride (TG) and total cholesterol (TC) in patients with fatty liver disease, but the precise mechanisms remain to be determined.

Purpose

This study aimed to investigate the effects and underlying mechanisms of XCHD on MAFLD.

Methods

The components of XCHD and XCHD-containing serum were characterized by UPLC/MS. High-fat diet and glucose-fructose water-induced MAFLD model in mice was established to evaluate the effects of X

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC12817532 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature