Systematic annotation and analysis of susceptibility genes associated with vaccine adverse events.

ABSTRACT: Susceptibility genes, including single-nucleotide polymorphisms (SNPs) in the DNA sequences, genetically predispose certain individuals to developing adverse events (AEs) following vaccination. Such AEs are often undetected in initial clinical safety trials during vaccine licensing evaluations. Therefore, a comprehensive understanding of susceptibility genes is crucial for vaccine development, safety monitoring, and precision immunization. VaegenDB is a web-based centralized database and analysis system designed for managing, storing, and analyzing susceptibility genes associated with vaccine AEs. Basic information on these genes and supporting evidence are curated from peer-reviewed literature, while more detailed gene, AE, and vaccine data are automatically extracted from existing databa

SUBMITTER: Song Q 

PROVIDER: S-EPMC12817545 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature