Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis.

ABSTRACT:

Background

Senile bone-fat imbalance poses a significant public health burden in aging populations. This study investigates how aging affects the heterogeneity of mesenchymal stem cell (MSC)-derived apoptotic vesicles (apoVs) and develops a therapeutic strategy to rectify age-related bone-fat metabolic disorders.

Results

Protein cargo analysis revealed that MSC-derived apoVs undergo age-dependent compositional remodeling, with Thy1 identified as a key biomarker progressively declining with donor aging. Functional validation confirmed Thy1's critical role in mediating apoV osteoinductive and anti-adipogenic capacities. Engineered Thy1-enriched apoVs, produced through magnetic-activated sorting and protein corona technology, significantly enhanced osteogenesis and suppressed a

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12817589 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature