Development and validation of a novel frailty model for the patients with newly diagnosed multiple myeloma.

ABSTRACT:

Background

The predominance of ageing in patients with multiple myeloma (MM) results in at least 30% of patients being classified as frail at diagnosis. Compared with healthy individuals, frail individuals exhibit reduced treatment tolerance and lower quality of life, which are correlated with decreased survival rates. Although various frailty models for MM have been developed, challenges remain in their broad application and timely adjustment of treatment based on frailty evaluations across heterogeneous patient groups.

Methods

This retrospective study analysed data from 606 patients with newly diagnosed MM at Xijing Hospital between May 2006 and August 2022. The dataset was randomly divided into a development set (N = 424) and a validation set (N = 182). A novel frailty mo

SUBMITTER: Tian B 

PROVIDER: S-EPMC12817602 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature