Exploring the regulatory mechanisms of differentially expressed circRNAs during bovine intramuscular adipogenic differentiation.

ABSTRACT:

Background

Intramuscular fat (IMF) accumulation plays a crucial role in determining beef quality. However, the molecular mechanisms regulating adipogenesis within bovine tissue remain unclear.

Results

This study conducted a comprehensive reanalysis of circular RNAs (circRNAs) transcriptomes using Temporal Clustering Analysis (TCA) to characterize their dynamic expression during the differentiation of bovine intramuscular preadipocytes across four time points. TCA revealed eight distinct clusters. Clusters 2 and 6 were selected due to exhibiting inverse expression trajectories that suggest stage-specific regulatory functions during early differentiation and late adipocyte maturation, respectively. Differential expression analysis identified 40 circRNAs which were dynamically

SUBMITTER: Abebe BK 

PROVIDER: S-EPMC12817609 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature