Life's essential 8 and non-alcoholic fatty liver disease: unmasking depressive symptoms' mediating role.

ABSTRACT:

Objectives

Aimed to reveal the complex associations between Life's Essential 8 (LE8), depressive symptoms and nonalcoholic fatty liver disease (NAFLD), and to explore the mediating role of depressive symptoms in the pathways of LE8 components affecting NAFLD.

Methods

Based on nationally representative data of 8908 adults ≥ 20 years from the 2005-2018 National Health and Nutrition Examination Survey (NHANES), weighted logistic, regression, restricted cubic spline(RCS), threshold effect and bootstrap mediated-effects analyses were used to assess the association between LE8, NAFLD and depressive symptoms associations, and stratified analysis reveals the heterogeneity of the association in population.

Results

Each one-point increase in the LE8 was associated with a reduce

SUBMITTER: Liu S 

PROVIDER: S-EPMC12817621 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature