Second-generation capsule endoscopy for the detection of colorectal polyps: An updated systematic review and comparative meta-analysis of prospective studies.

ABSTRACT:

Objectives

Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. Colonoscopy (CO) is the gold standard for screening, but its invasive nature and low adherence limit its use. Second-generation capsule endoscopy (CCE-2) emerges as a non-invasive alternative. This study aimed to evaluate the diagnostic accuracy of CCE-2 in detecting colorectal polyps, using CO as the reference standard.

Methods

A systematic review and meta-analysis of prospective studies in adults undergoing CCE-2 followed by CO was performed. Searches were conducted in PubMed, EMBASE and Cochrane up to May 2025. Diagnostic accuracy metrics were pooled using a Bayesian bivariate model with construction of HSROC curves. To assess clinical impact,

SUBMITTER: Camara CF 

PROVIDER: S-EPMC12817651 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature