Uncovering metabolic shifts: an ¹H-NMR study on the dual influence of HIV/TB coinfection and ART.

ABSTRACT:

Background

Human immunodeficiency virus (HIV) and tuberculosis (TB) coinfection pose a substantial global health burden, with each infection amplifying the immune and metabolic impacts of the other. Investigating the compounded metabolic disruptions in HIV/TB coinfection and how these are modulated by antiretroviral therapy (ART) offers information into disease mechanisms and therapeutic strategies.

Methods

This study used untargeted proton nuclear magnetic resonance metabolomics to characterize the urine samples from three participant groups: healthy controls, treatment-naive HIV/TB coinfected individuals, and ART-treated HIV/TB coinfected individuals.

Results

Significant metabolite shifts were observed across gut microbiota, energy, amino acid, and carbohydrate meta

SUBMITTER: Ahumada Prado SP 

PROVIDER: S-EPMC12817673 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature