Association of MALAT1 gene polymorphisms with neuroblastoma susceptibility in children from Jiangsu Province.

ABSTRACT:

Background

Neuroblastoma, a clinically heterogeneous pediatric tumor, has varying outcomes ranging from spontaneous regression to aggressive metastasis. Recent studies have emphasized non-coding RNAs, particularly long non-coding RNAs (lncRNAs), as crucial regulators of cancer epigenetics. MALAT1 is a dual oncogenic lncRNA with some therapeutic potential but has rarely been studied in neuroblastoma.

Methods

We genotyped three MALAT1 polymorphisms (rs591291 C > T, rs619586 A > G, and rs3200401 C > T) in 402 neuroblastoma patients and 473 controls via TaqMan. Further stratification analysis was conducted to evaluate the potential associations of rs591291 and rs619586 with neuroblastoma risk. Through the GTEx database, we also investigated the impact of MALAT1 gene polymorphism

SUBMITTER: Lian Y 

PROVIDER: S-EPMC12817674 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature