Cannabidiol does not cause DNA double-strand breaks in a human liver-derived cell model.

ABSTRACT:

Background

Cannabidiol (CBD) is a non-psychoactive cannabinoid with potential therapeutic applications, including anti-inflammatory, analgesic, and anticancer effects. However, experts raised concerns about its potential to induce DNA damage and chromosomal aberrations at low concentrations. Notably, these studies used liver cell lines, which may not fully reflect the metabolic processing of CBD, potentially limiting the generalizability of their findings. This study investigated the short time effects of CBD on DNA double-strand breaks (DSBs) and proliferation in the human liver-derived cell line HepG2.

Methods

HepG2 cells were treated with CBD (5 - 50 [Formula: see text], 3 - 72h incubation). To investigate potential imbalances in the expression of cannabinoid receptors 1

SUBMITTER: Weiss R 

PROVIDER: S-EPMC12817681 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature