CXCR3 gene as a therapeutic target in colorectal cancer.

ABSTRACT:

Background

Cancers, especially colorectal cancer, are among the most common and deadly diseases in the world, and their incidence is increasing in various countries. Current therapeutic methods, such as chemotherapy, surgery, and immunotherapy, have failed to provide successful treatment without side effects. Therefore, identifying effective therapeutic targets is crucial. Several studies have demonstrated that the expression of the CXCR3 gene, a member of the GPCR family, is elevated in colorectal cancer.

Methods

In this study, the effect of targeting the CXCR3 gene on the HCT-116 line, a colorectal cancer cell line, was investigated via gene-specific targeting. For this purpose, specific DNAzymes were designed, and the impact of CXCR3 downregulation on cancer cell developm

SUBMITTER: Azarshin SZ 

PROVIDER: S-EPMC12817714 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature