Structural covariance network in the striatum is modulated by non-suicidal self-injury in adolescents with major depressive disorder.

ABSTRACT:

Background

Adolescents with major depressive disorder (MDD) significantly affect the development and well-being of this group. Approximately one-third of these adolescents engage in non-suicidal self-injury (NSSI) behavior, which notably increases their risk of suicide. Striatal abnormalities, particularly in the corticostriatal circuit, have been implicated in depression. The striatum is a crucial part of the reward system, and its abnormal connectivity with other brain regions within the system has been linked to repetitive NSSI behavior in adolescents. This study aims to investigate structural covariance (SC) connectivity patterns within the corticostriatal circuitry in adolescents with MDD and explore how NSSI modulates these patterns.

Methods

This study employed SC anal

SUBMITTER: Luo Z 

PROVIDER: S-EPMC12817721 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature