Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study.

ABSTRACT:

Background

Verbal fluency impairment is a common cognitive deficit in epilepsy that further increases the burden of the disease. Current anti-seizure medications mainly target seizure control but rarely improve cognition and may even worsen it in the patients. Neuromodulation has shown potential to control seizures and improve cognition simultaneously by stimulating specific nuclei or neural circuits, but the precise targets for verbal fluency deficits remain unclear, particularly in patients unaffected by anti-seizure medication. Therefore, investigating the neural mechanisms in newly diagnosed epilepsy (NDE) patients is essential for developing targeted interventions. This study aimed to explore brain network abnormalities and their relationship with verbal fluency deficits in ND

SUBMITTER: Liu F 

PROVIDER: S-EPMC12817765 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature