Test-adjusted estimation for pertussis incidence in greater Toronto, Canada, 1993-2006.

ABSTRACT:

Background

Pertussis remains a major public health concern, particularly affecting young children. While most identified cases occur in this group, the burden among older children and adults who undergo less frequent testing is not well characterized.

Methods

We analyzed pertussis testing and case data in the Greater Toronto Area from 1993 to 2006. We applied a meta-regression-based method for test adjustment by age and sex, estimating case counts in each demographic group as if they were tested at the same rate as the most tested group (< 1-year males).

Results

Before adjustment, incidence was highest in the < 1-year group and declined with age, with the ≥ 80-year group having an incidence rate ratio (IRR) of 0.011 (95% CI: 0.006-0.020) relative to male children aged

SUBMITTER: Lee CE 

PROVIDER: S-EPMC12817766 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature