Risk of gastrointestinal cancers in patients with primary Sjogren's syndrome in Korea: a nationwide retrospective cohort study.

ABSTRACT:

Background

The risk of non-Hodgkin's lymphoma in patients with primary Sjögren's syndrome (pSS) is well established. However, the association between pSS and the risk of gastrointestinal cancers remains underexplored. This study aims to assess the risk of gastrointestinal cancers in pSS patients in Korea compared with the general population.

Methods

We included 320,082 participants from National Health Insurance Service-National Sample Cohort (NHIS-NSC) database. Of these, there were 850 patients with pSS and 319,232 in the non-pSS group. All participants were followed-up until 2019 or the development of gastrointestinal cancers, whichever occurred first. Hazard ratio (HR) and 95% confidence intervals (95% CI) for gastrointestinal cancers were calculated by multivariable Cox

SUBMITTER: Shin S 

PROVIDER: S-EPMC12817787 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature