Photobiomodulation limits oral ulcer development by regulating the immune response.

ABSTRACT:

Background

Oral ulcer (OU) is among the most common oral mucosal disease, and immune factors are generally considered to play crucial roles in OU. Photobiomodulation (PBM) therapy can promote healing and alleviate pain; however, the effect and mechanism of early ulceration remain unclear.

Objective

This study aimed to establish a model of early persistent aggravation, assess the impact of PBM on early persistent aggravation, and map the involvement of different immune cells.

Methods

In this study, an OU model was established in C57BL/6 mice, and the mice were subsequently treated with PBM. Haematoxylin and eosin staining, stem cell immunofluorescence, and collagen III immunohistochemical staining were used to evaluate the wound healing process. Flow cytometry and immu

SUBMITTER: Zhu S 

PROVIDER: S-EPMC12817794 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature