Functional regulatory roles of HNF1B in promoting cell proliferation, migration, invasion and fate decision of hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide, with complex pathogenesis and poor clinical prognosis. It was shown that hepatocyte nuclear factor 1β (HNF1B) is strongly expressed in hepatocyte and involved in liver development. Relevant studies have shown that HNF1B can be used as a marker for the identification of hepatocellular cholangiocarcinoma. However, regarding the mechanism by which HNF1B regulates the behavior of cancer cells to influence the development, malignancy and metastasis ability of HCC, is poorly understood at present.

Methods

In this study, the proliferation, migration, invasion, and apoptosis of liver cancer cells was investigated by modulating the expression of HNF1B in HCC cells. Furthermore, bioinformatics analysis: i

SUBMITTER: Zhao P 

PROVIDER: S-EPMC12817800 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature