MIR4435-2HG: a key player in the novel lncRNA prognostic signatures causes early metastasis after tumor resection and poor prognosis for esophageal squamous cell carcinoma.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is a major histopathological type of esophageal cancer. Tumor metastasis is a critical factor that dramatically worsens the prognosis, leading to a decline in survival rates. Understanding the molecular mechanisms underlying metastasis and identifying reliable biomarkers to predict metastasis susceptibility are essential for improving patient outcomes. This study aims to explore the role of lncRNA MIR4435-2HG in ESCC metastasis susceptibility and its potential as a prognostic biomarker.

Methods

We conducted a genome-wide analysis of gene expression in ESCC tissues from four patients with similar clinical characteristics but divergent prognoses to identify differentially expressed lncRNAs and mRNAs. We focused on the lncRNA

SUBMITTER: Qi P 

PROVIDER: S-EPMC12817812 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature