Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC.

ABSTRACT: Squalene epoxidase (SQLE) drives hepatocellular carcinoma (HCC) development via increased hepatic oxidative stress, a hallmark of ferroptosis. Although investigations have progressed, the precise link between SQLE and ferroptosis in HCC remains indistinct. In this study, multi-omics data were employed to identify ferroptosis-associated genes linked to SQLE in HCC, which were subsequently categorised into two prognostic risk categories. Kaplan-Meier analysis revealed patients allocated to the high-risk group exhibiting markedly poorer outcomes compared to those in the low-risk group, thereby underscoring the independent prognostic value of the ferroptosis-related prognostic signature in HCC. Furthermore, MTT assays further demonstrated that overexpression of SQLE conferred resistance to the

SUBMITTER: Yang X 

PROVIDER: S-EPMC12817838 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature