Association between serum sodium and the risk of sepsis-related liver injury: a cross-sectional study based on the MIMIC-IV database.

ABSTRACT:

Background

Sepsis-related liver injury (SRLI) is a common complication of sepsis, yet its mechanisms are unclear and the association between serum sodium (SNa) and SRLI has been rarely investigated.

Methods

This retrospective cross-sectional study utilized data from the MIMIC-IV database, focusing on adult intensive care unit (ICU) patients diagnosed with sepsis. The primary outcome was SRLI. SNa levels were categorized into hyponatremia, normonatremia, and hypernatremia groups based on clinical cutoffs for statistical analysis. Binary logistic regression was used to assess the independent association between SNa and SRLI, and the Generalized Additive Model (GAM) was applied to verify potential nonlinear associations. Sensitivity analyses were conducted to ensure the robustn

SUBMITTER: Li G 

PROVIDER: S-EPMC12817860 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature