Evidence for Maternal Autoantibodies in the Pathogenesis of Preterm Birth.

ABSTRACT: Complications from preterm birth are the leading cause of global mortality in children under age five^1,2. Spontaneous preterm labor is the most common cause of preterm delivery and is associated with a breakdown of maternal-fetal tolerance^3-5. However, the current understanding of the role of autoantibodies in this process has been limited to a handful of examples of pathogenic antibodies that occur with pregnancy complications^6-14. Here, we employ proteome-wide autoantibody profiling via phage display immunoprecipitation and sequencing (PhIP-seq) to identify autoreactivities associated with pregnancy as well as term or preterm delivery outcomes in maternal sera across eight cohorts of human pregnancy (n=2,194). We find that preterm pregnancies exhibit grea

SUBMITTER: Rackaityte E 

PROVIDER: S-EPMC12817887 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature