Bidirectional transfer of pritelivir across term human placenta and its effect on placental functions.

ABSTRACT: Genital herpes in pregnancy is treated with nucleoside analog drugs such as acyclovir to reduce the risk of mother-to-neonate transfer of the virus. Pritelivir is a novel anti-herpes simplex virus drug that is effective against acyclovir-resistant viral strains and is currently in phase 3 clinical trial for nonpregnant subjects. Here, we determined bidirectional transfer of pritelivir across dually perfused term human placental lobule and its effect on placental tissue viability and functionality ex vivo. We also assessed potential cytotoxicity of pritelivir in vitro using human choriocarcinoma-derived trophoblast-like cells (BeWo, b30 clone) and human umbilical vein endothelial cells. Our data demonstrated the transfer of pritelivir across the placenta ex vivo from the maternal to the fet

SUBMITTER: Bryant VF 

PROVIDER: S-EPMC12817888 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature