Integrative multi-omics analysis reveals gut-skin axis mechanisms and novel therapeutic target <i>GALE</i> in atopic dermatitis.

ABSTRACT: The gut-skin axis represents a critical but poorly understood pathway in atopic dermatitis (AD) pathogenesis. This study aimed to establish causal relationships between gut microbiota and AD risk while identifying key molecular bridges and therapeutic targets. We integrated multiple analytical approaches, including single-cell RNA sequencing analysis of skin biopsies from five AD patients and four healthy controls, intercellular communication network analysis, pseudotime trajectory inference, reverse drug prediction, molecular docking, and molecular dynamics simulations. Analysis revealed increased keratinocyte heterogeneity and enhanced immune cell communication in atopic dermatitis (AD) samples. Intersection analysis between gut microbial metabolite-associated genes and skin pathology-re

SUBMITTER: Cao F 

PROVIDER: S-EPMC12817900 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature