Genomic diversity and adaptive resistance mechanisms in <i>Pseudomonas aeruginosa</i> from bronchiectasis.

ABSTRACT: Pseudomonas aeruginosa is a predominant colonizer of airways in non-cystic fibrosis bronchiectasis (NCFB), yet its adaptive mechanisms remain poorly understood. This study investigates the genetic characteristics, virulence variation, and resistance mechanisms of 66 P. aeruginosa isolates derived from NCFB patients. Whole-genome sequencing revealed extensive genetic diversity, encompassing 53 sequence types and a predominance of the O6 serotype (30/66, 45.5%). Phylogenetic analysis indicated that most NCFB isolates were acquired independently, with limited evidence of transmission. Extensive loss-of-function mutations were identified, with mucA mutations present in 90.6% (29/32) of mucoid and 67.6% (23/34) of non-mucoid isolates. Most mucA mutations were

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC12817961 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature