Mitochondrial DNA Variation, Antiretroviral Therapy, and Incidence of Diabetes Among Men With and Without HIV.

ABSTRACT:

Background

Mitochondrial dysfunction is implicated in the development of diabetes mellitus (DM), which is more common in people with HIV (PWH) than in people without HIV (PWoH). Variation in mitochondrial DNA (mtDNA) and mitochondrial-toxic antiretroviral therapy (ART) may influence the susceptibility to DM but is underexplored in men with HIV.

Methods

Men from the Multicenter AIDS Cohort Study (MACS) without DM and with fasting glucose data were included. Type 2 DM was defined by fasting glucose ≥ 126 mg/dL, DM medication use, a DM diagnosis, or hemoglobin A1c ≥ 6.5%. Exposure to mitochondrial-toxic ART (D-drugs or zidovudine) was categorized as a binary variable based on ever or never exposed. Mitochondrial DNA haplogroups were determined using HaploGrep from genotyping da

SUBMITTER: Cronin C 

PROVIDER: S-EPMC12817993 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature