Calcium Phosphate Mineralization of Bulk Alginate Hydrogels Composites With Metal and Metal Oxide Nanoparticles.

ABSTRACT: Alginate hydrogels are promising materials for biomedical applications due to their biocompatibility and ability to mimic the extracellular matrix. However, poor mechanical stability and limited bioactivity hinder their wider clinical application. This problem can be overcome by incorporating nanoparticles (NPs) and calcium phosphates (CaPs). In this study, the simultaneous gelation and CaP mineralization of bulk alginate hydrogels in the presence of antimicrobial silver (AgNP), copper oxide (CuONP), and zinc oxide (ZnONP) was investigated. Calcium-deficient hydroxyapatite forms at pH 7.4, and stable amorphous calcium phosphate at pH 9.0. The incorporation of NPs influences the morphology of mineral phases but not composition. Rheological testing revealed that mineralized hydrogels exhibit

SUBMITTER: Milisav AM 

PROVIDER: S-EPMC12818023 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature