Development and characterization of an autoresuscitation test for preclinical SUDEP models.

ABSTRACT: The rate of sudden unexpected death in epilepsy (SUDEP) is ~1 per 1000 patients each year. Terminal events reportedly involve repeated and prolonged apnea, suggesting a failure to autoresuscitate. To better understand the mechanisms and identify novel therapeutics, standardized tests to screen for autoresuscitation efficacy are needed in preclinical SUDEP. To investigate the efficacy of the autoresuscitation response and potential contribution to SUDEP susceptibility, we adapted an anoxia-induced autoresuscitation test. The test was optimized to allow for survival of most wild-type (WT) mice, whereas autoresuscitation failure occurred for most Kcna1^-/- mice, a preclinical model of SUDEP. Using whole-body plethysmography, we assessed ventilatory parameters, gasp-apnea dynamics, a

SUBMITTER: Iyer SH 

PROVIDER: S-EPMC12818031 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature