Therapeutic Effects of Gallic Acid and Alpha-Tocopherol on Adenine-Induced Chronic Kidney Disease in Male Wistar Rats.

ABSTRACT: Chronic kidney disease (CKD) is a major health issue associated with oxidative stress and inflammation that leads to progressive renal damage. Natural antioxidants, gallic acid (GA) and alpha-tocopherol (AT), have gained attention for their strong free radical-scavenging, inflammation-reducing, and tissue-repairing properties, and their individual or combined administration may offer therapeutic potential in CKD management. This experiment was designed to explore the potential ameliorative effects of GA and AT against CKD induced by adenine in male rats. Adult rats weighing 180-220 g (n = 48) were distributed among eight experimental groups. Except for Group I (control), all groups received a standard rat diet supplemented with 0.75% (w/w) adenine for 4 weeks to induce CKD. During t

SUBMITTER: Baro MR 

PROVIDER: S-EPMC12818050 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature