Temporal trends in progression risk in smoldering myeloma: a systematic review.

ABSTRACT:

Background

Diagnostic advancements and classification updates appear to have reshaped the natural history of smoldering multiple myeloma (SMM), though this evolution has not been empirically quantified. We conducted a systematic review to evaluate temporal changes in SMM prognosis.

Methods

PubMed, EMBASE and the Cochrane library databases were searched from January 1990 to November 2025, yielding 1415 reports, of which 14 studies met inclusion criteria. To reconstruct individual-level data, published time to progression (TTP) curves were digitized using a Shiny web application. Kaplan-Meier (KM) survival curves and meta-analyses were generated in RStudio. PROSPERO ID 1068697.

Findings

Progression risk at two and ten years for all-risk patients was 22.8% and 60.1%, res

SUBMITTER: Ludwig H 

PROVIDER: S-EPMC12818083 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature